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While serum GGT activity is commonly used as a quick, inexpensive, and reliable means of assessing liver function, recent epidemiological studies have shown that it may also be an indicator of an increased risk of metastatic prostate cancer and advanced urothelial carcinoma [54,55,56]

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The honest answer is that both very low and, in rare cases, very high B12 levels may be linked to shedding, but the strongest evidence points to deficiency as the real concern, not normal supplements